Assignment of polymorphic species of insulin analogues in ion mobility mass spectroscopy

نویسندگان

  • Maely P. Fávero-Retto
  • Luiz Henrique Guerreiro
  • Cássio M. Pessanha
  • Leonardo C. Palmieri
  • Luís Maurício T.R. Lima
چکیده

Electrospray ionization - ion mobility spectrometry - mass spectrometry (ESI-IMS-MS) allows the identification of protein polymorphic distribution of protein conformers and oligomers. We report the detailed identification of the species observed with commercially available pharmaceutical preparation of wild-type, regular human insulin.

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عنوان ژورنال:

دوره 10  شماره 

صفحات  -

تاریخ انتشار 2017